Allogene Therapeutics Inc (NASDAQ:ALLO) Reports Narrower-Than-Expected Q2 2025 Loss, Shares Rise Modestly

Allogene Therapeutics Inc (NASDAQ:ALLO [https://www.chartmill.com/stock/quote/ALLO/profile]) reported its second-quarter 2025 financial results, posting a net loss of $50.9 million, or $0.23 per share, compared to analyst expectations of a loss of $0.28 per share. Revenue for the quarter was $0, missing the estimated $1.86 million. Despite the revenue shortfall, the narrower-than-expected loss appears to have been received positively by the market, with shares rising nearly 1% in after-hours trading.

KEY FINANCIAL TAKEAWAYS

* EARNINGS PER SHARE (EPS): Reported at -$0.23, beating the consensus estimate of -$0.28.
* REVENUE: Came in at $0, below the expected $1.86 MILLION.
* CASH POSITION: The company ended Q2 with $302.6 MILLION in cash, cash equivalents, and investments, projecting a runway into the second half of 2027.
* OPERATING EXPENSES: Total operating expenses were $56.8 MILLION, down from $71.4 MILLION in the prior-year quarter, reflecting cost discipline.

MARKET REACTION

The stock’s modest after-hours gain suggests investors were more focused on the improved bottom-line performance rather than the lack of revenue. Over the past month, shares have declined ~16.9%, likely due to broader market conditions and sector-specific pressures. The immediate post-earnings uptick indicates some relief that losses were not as steep as feared.

BUSINESS AND PIPELINE UPDATES

Beyond the financials, Allogene highlighted progress across its clinical programs:

* ALPHA3 TRIAL (CEMA-CEL IN LBCL): The pivotal Phase 2 trial is proceeding as a randomized study comparing cema-cel after standard lymphodepletion versus observation. A futility analysis is expected in the first half of 2026.
* RESOLUTION TRIAL (ALLO-329 IN AUTOIMMUNE DISEASE): Enrollment has begun in this Phase 1 basket trial, with initial data anticipated in H1 2026.
* TRAVERSE TRIAL (ALLO-316 IN RENAL CELL CARCINOMA): Updated Phase 1b data presented at ASCO 2025 showed encouraging responses, and the company has aligned with the FDA on a pivotal trial design.

OUTLOOK VS. ANALYST ESTIMATES

Allogene did not provide specific revenue or EPS guidance for upcoming quarters, but analysts currently project:

* Q3 2025 REVENUE: $1.86 MILLION (vs. no company-provided forecast).
* Q3 2025 EPS: -$0.24 (vs. no company-provided forecast).
* FULL-YEAR 2025 REVENUE: $5.57 MILLION (vs. no company-provided forecast).
* FULL-YEAR 2025 EPS: -$1.05 (vs. no company-provided forecast).

Given the lack of formal guidance, the market’s reaction remains tied to clinical progress rather than near-term financial performance.

CONCLUSION

Allogene’s Q2 results reflect a company still in heavy investment mode, with clinical milestones taking precedence over revenue generation. The beat on EPS and a solid cash position may reassure investors, but the lack of revenue remains a concern. The stock’s muted but positive after-hours reaction suggests cautious optimism, particularly given the progress in key trials.

For more detailed earnings and estimates, visit Allogene Therapeutics' earnings page [https://www.chartmill.com/stock/quote/ALLO/earnings-estimates].

_Disclaimer: This article is not investment advice. Investors should conduct their own research or consult a financial advisor before making decisions._