BillionToOne raises $273.1m in IPO

BillionToOne has become a newly minted public company, raising $273.1m in an upsized initial public offering (IPO), despite the longest government shutdown in US history hampering those wishing to join the stock exchange.

The US-based company sold around 4.5 million shares of its common stock at $60 each. The molecular test developer initially offered around 3.8 million shares that were expected to fall between $49 and $55 each.

BillionToOne’s IPO has given it a market valuation at around $2.6bn. The molecular diagnosis company’s shares are set to begin trading on the Nasdaq Global Select Market from 6 November under the ticker symbol ‘BLLN’.

The IPO marks a culmination of a successful past few years for BillionToOne. At the JP Morgan Healthcare conference in San Francisco in January 2025, the company announced that it had achieved 2024 revenues of $153m, more than doubling its $72m profits in 2023.

The 2024 performance was primarily driven by BillionToOne’s prenatal testing business segment that has captured market share of 15% in the US, according to the company. Its lead product in the segment is UNITY Fetal Risk Screen, a non-invasive prenatal test (NIPT) to assess a foetus’s risk of certain inherited conditions. Using cell-free foetal DNA from a mother's blood sample, UNITY screens for conditions, including cystic fibrosis, sickle cell disease, and spinal muscular atrophy (SMA).

The state of medtech IPOs in 2025

The conclusion of BillionToOne’s IPO makes it one of the biggest in the medtech space for 2025. The medtech IPO season kicked off with a $204m raise for artificial pancreas manufacturer Beta Bionics in January, and a $202m raise for wearable defibrillator developer Kestra Medical Technologies in March.

HeartFlow’s $364m IPO, which saw the AI-based coronary artery disease (CAD) platform developer debut with a $2.2bn valuation on the Nasdaq on 8 August, has proven to be the biggest medtech IPO in the second half of 2025.

While this year has not been flush with medtech IPOs, a recent report by EY suggests there continues to be an ongoing appetite for medtechs to go public, with more IPOs expected in 2026.

Commenting on the report's findings during a webinar, EY's global medtech lead John Babitt said: “We would also expect to see a lot of dual process, where companies move through and evaluate going public, but also run a mini process from an M&A price check standpoint."

"BillionToOne raises $273.1m in IPO" was originally created and published by Medical Device Network, a GlobalData owned brand.

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