Publication relating to transparency notifications

REGULATED INFORMATION

Publication relating to transparency notifications

Mont-Saint-Guibert(Belgium), October 3, 2025, 10:30 pm CET / 4:30 pm ET – In accordance with article 14 of the Act of 2 May 2007 on the disclosure of large shareholdings, Nyxoah SA (Euronext Brussels/Nasdaq: NYXH) announces that it received a transparency notification as detailed below.

Vestal Point Capital

On October 1, 2025, Nyxoah received a transparency notification from Vestal Point Capital following an acquisition or disposal of voting securities or voting rights. Based on the notification, Vestal Point Capital holds 1,113,575 voting rights, representing 2.97% of the total number of voting rights on September 24, 2025 (37,544,782).

The notification dated September 30, 2025 contains the following information:

Reason for thenotification:

Acquisition or disposal of voting securities or voting rights Downward crossing of the lowest thresholdNotification by: a parent undertaking or a controlling person Persons subject to the notification requirement:

Vestal Point Capital, LLC (with address at 632 Broadway, Suite 602, New York, NY 10012, USA)Vestal Point Capital, LP (with address at 632 Broadway, Suite 602, New York, NY 10012, USA)Ryan Wilder (with address at 632 Broadway, Suite 602, New York, NY 10012, USA)Date on which the threshold was crossed: September 24, 2025Threshold that is crossed: 3%Denominator: 37,544,782Notifieddetails:

A) Voting rightsPrevious notificationAfter the transaction # of voting rights# of voting rights% of voting rightsHolders of voting rights Linked to securitiesNot linked to the securitiesLinked to securitiesNot linked to the securitiesRyan Wilder0000.00%0.00%Vestal Point Capital, LLC0000.00%0.00%Vestal Point Capital, LP1,809,8431,113,575 02.97%0.00%Subtotal1,809,8431,113,575 2.97% TOTAL1,113,575 2.97%

Full chain of controlled undertakings through which the holding is effectively held: Vestal Point Capital, LP (investment manager) is controlled by Vestal Point Capital, LLC (general partner). Vestal Point Capital, LLC is controlled by Mr. Ryan Wilder (managing member).Additional information: Vestal Point Capital, LP is the investment management company that can exercise the voting rights at its discretion, in the absence of specific instruction.

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Contact:
Nyxoah
John Landry, CFO
[email protected]

Attachment

2025 10 03 PR Transparency notification (Vestal Point) (ENG)