[Pfizer Headquarters in New York]
georgeclerk
Pfizer (NYSE:PFE [https://seekingalpha.com/symbol/PFE]) has agreed to acquire Metsera (NASDAQ:MTSR [https://seekingalpha.com/symbol/MTSR]) in a deal worth $47.50 per share in cash, valuing the company at $4.9 billion upfront, with the potential for shareholders to receive up to an additional $22.50 per share through contingent value rights tied to future milestones.
Metsera, up nearly 60% in premarket trading, is a clinical-stage biopharmaceutical company accelerating the next generation of medicines for obesity and cardiometabolic diseases.
Talks to acquire Metsera (NASDAQ:MTSR [https://seekingalpha.com/symbol/MTSR]) surfaced just months after the biotech firm's blockbuster debut on Nasdaq, and the $47.50-per-share offer reflects a roughly 42.5% premium over the company's Friday closing price of $33.32, which pegged its market value at about $3.5 billion.
Metsera has a portfolio of therapeutic candidates and combinations with four programs in clinical development and several next-generation programs with IND-enabling studies ongoing, aimed at addressing key unmet needs via fewer injections while achieving improved efficacy and tolerability.
This includes MET-097i, a weekly and monthly injectable GLP-1 receptor agonist, both in Phase 2 development, and MET-233i, a monthly amylin analog candidate being evaluated as monotherapy and in combination with MET-097i in Phase 1 development.
The company also has two oral GLP-1 RA candidates expected to begin clinical trials imminently and additional preclinical nutrient-stimulated hormone therapeutics.
_Updates story with Pfizer's statement [https://seekingalpha.com/pr/20239248-pfizer-to-acquire-metsera-and-its-next-generation-obesity-portfolio] and share movement. PFE up 1.8%._
MORE ON PFIZER, METSERA
* Pfizer: Dividend Cushion Ratio Brings Yield Sustainability Into Question [https://seekingalpha.com/article/4824158-pfizer-dividend-cushion-ratio-brings-yield-sustainability-into-question]
* Pfizer: Cheap Doesn't Mean Good [https://seekingalpha.com/article/4823755-pfizer-cheap-doesnt-mean-good]
* Why I Sold Pfizer To Buy Novo Nordisk [https://seekingalpha.com/article/4822764-why-i-sold-pfizer-to-buy-novo-nordisk]
* Trump considering website for consumers to buy discounted prescription drugs - report [https://seekingalpha.com/news/4496759-trump-considering-website-consumers-buy-discounted-prescription-drug]
* CDC vaccines panel votes unanimously to change COVID-19 vaccine recommendation [https://seekingalpha.com/news/4496718-cdc-vaccines-panel-votes-unanimously-to-change-covid-19-vaccine-recommendation]
Pfizer nears $7.3B takeover of weight loss drugmaker Metsera, FT reports
Published 1 month ago
Sep 22, 2025 at 5:45 AM
Neutral
Auto