Ascendis Pharma struggles after report of Yorvipath patient death

[Dark, death and body of person in hospital on bed for healthcare, medical or tragic accident. Eternity, mortality and rest with cadaver of patient in clinic for afterlife, emergency or mistake]
Sean Anthony Eddy/E+ via Getty Images

* Ascendis Pharma at one point on Monday was down ~12% before closing off just 2.5% after the FDA adverse event report database was updated to reflect the death of an individual taking the hypoparathyroidism drug Yorvipath (palopegteriparatide).
* The database entry indicated [https://fis.fda.gov/sense/app/95239e26-e0be-42d9-a960-9a5f7f1c25ee/sheet/6b5a135f-f451-45be-893d-20aaee34e28e/state/analysis]that the patient also had HER2+ breast cancer and experienced reactions including hypocalcemia, hypocalcemic seizures, and postoperative wound infection.
* A death reported to the FDA Adverse Event Reporting System does not necessarily mean a drug the patient was taking contributed to it.
* Analyst Luca Issi of RBC Capital, who rates Ascendis at outperform, said that given the patient had breast cancer, had a complex clinical situation, and was on multiple medications, it is uncertain if Yorvipath caused or is even correlated with the death.

MORE ON ASCENDIS PHARMA

* Ascendis Pharma A/S (ASND) Presents at Wells Fargo 20th Annual Healthcare Conference 2025 Transcript [https://seekingalpha.com/article/4823437-ascendis-pharma-a-s-asnd-presents-at-wells-fargo-20th-annual-healthcare-conference-2025]
* Ascendis: After Long Bull Run, New Commercial Challenges Suggest Rating Downgrade [https://seekingalpha.com/article/4815660-ascendis-after-long-bull-run-new-commercial-challenges-rating-downgrade]
* Ascendis Pharma A/S (ASND) Q2 2025 Earnings Call Transcript [https://seekingalpha.com/article/4811676-ascendis-pharma-a-s-asnd-q2-2025-earnings-call-transcript]
* Ascendis submits application to market TransCon CNP in EU [https://seekingalpha.com/news/4502791-ascendis-submits-application-to-market-transcon-cnp-in-eu]
* Ascendis Pharma reports Q2 results [https://seekingalpha.com/news/4481753-ascendis-pharma-reports-q2-results]